美常安联合柳氮磺吡啶治疗溃疡性结肠炎的疗效及对血清TNF-α、IL-6、IL-8水平的影响

被引：22

作者：

李杨麟

喻晓东

苏林

唐运东

秦漓漓

王芬利

机构：

[1] 桂林市第二人民医院消化内科

来源：

现代生物医学进展 | 2016年 / 16卷 / 10期

关键词：

美常安; 柳氮磺吡啶; 溃疡性结肠炎; 炎症;

D O I：

10.13241/j.cnki.pmb.2016.10.032

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

目的:探索美常安联合柳氮磺吡啶治疗溃疡性结肠炎(UC)的疗效,及对血清TNF-α、IL-6、IL-8水平的影响。方法:选择自2012年9月至2014年12月我院收治的100例UC患者,按照随机数表法分成对照组和观察组,每组50例。对照组患者口服给予柳氮磺吡啶,观察组患者口服给予美常安联合柳氮磺吡啶治疗。统计分析两组患者的临床有效率、症状改善、不良反应发生情况及治疗前后患者血清中TNF-α、IL-6、IL-8水平的变化。结果:观察组中总有效率为92.00%显著高于对照组中总有效率为48.00%(P<0.05);两组患者治疗后的主要临床症状较治疗前均有明显改善(P<0.05),且观察组患者治疗后主要症状缓解率明显高于对照组(P<0.05);两组患者治疗后血清中TNF-α、IL-6、IL-8水平均显著低于治疗前,且观察组明显低于对照组(P<0.05);两组患者不良反应发生率之间的差异无统计学意义(P>0.05)。结论:美常安联合柳氮磺吡啶治疗UC具有良好的临床疗效,能显著改善患者的临床症状和患者血清中炎症因子的水平,值得在临床上推广使用。

引用

页码：1926 / 1929

页数：4

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