乙型肝炎病毒基因变异对干扰素治疗慢性乙型肝炎疗效的影响

被引：6

作者：

龚启明

韩永年

张欣欣

陆志檬

机构：

[1] 上海第二医科大学附属瑞金医院传染病科

来源：

诊断学理论与实践 | 2002年 / 03期

关键词：

乙型肝炎病毒; 基因变异; 干扰素;

D O I：

暂无

中图分类号：

R512.62 [];

学科分类号：

100401 ;

摘要：

目的 :探讨乙型肝炎病毒基因不同位点变异及基因型对干扰素疗效的影响。方法 :研究 17例HBeAg阳性慢性乙型肝炎病人的临床表现、生化、血清学和病毒学指标 ,并分析这些病人干扰素治疗 (IFN -α2b 3MU ,每周三次 ,疗程 6个月 )前血清标本中的病毒X基因和前c c基因的DNA序列。结果 :所有发生T1 76 2 -A1 76 4突变的 5例病人对干扰素治疗均有应答 ,而其余 12例病人中仅 2例有应答。在 5例既有前c区A1 896 变异又有c区抗原决定簇aa 10 7- 118变异的病人中 ,4例无应答 ,1例有应答。其他 3例有A1 896 位点变异的病人中 ,2例同时伴有 1～ 2处淋巴细胞表位变异的病人有应答 ,而 1例伴有 5处淋巴细胞表位变异的病人无应答。应答者的血清HBVDNA复制水平低而抗HBc -IgM滴度高。所有病人的血清HBVDNA基因型均为B型或C型。结论 :提示HBV基因变异、血清病毒载量和抗HBc -IgM滴度等可能是干扰素治疗效果的预测指标 ,但有待临床和实验室研究的进一步验证。

引用

页码：45 / 48

页数：4

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