大鼠局灶缺血预处理诱导的脑缺血耐受中热休克蛋白70的表达及其意义

被引：3

作者：

郝玉曼

罗祖明

周东

机构：

[1] 四川大学华西医院神经内科

来源：

临床神经病学杂志 | 2003年 / 05期

关键词：

缺血预处理; 缺血耐受; 脑缺血; 热休克蛋白;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

摘要：

目的　研究局灶脑缺血预处理对热休克蛋白 70 (HSP70 )表达和脑缺血耐受的影响。方法　SD大鼠随机分为 3组 :预缺血组、假手术组及对照组 ,前两组分别在 2小时大脑中动脉缺血 (MCAO)前 3天给予10分钟的预缺血或假手术 ,MCAO后 2 4小时处死 ,对照组给予两次相隔 3天的假手术 ,比较各组梗死体积及HSP70的表达。结果　预缺血组梗死体积较假手术组减少 5 2 5 4 % (P <0 0 1) ,HSP70表达高于假手术组及对照组 (P <0 0 1)。结论　 10分钟大脑中动脉预缺血可有效诱导缺血耐受 ,增加HSP70表达。HSP70表达上调可能是局灶性脑缺血耐受产生的分子机制之一

引用

页码：284 / 286

页数：3

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