大鼠局灶缺血预处理诱导的脑缺血耐受中热休克蛋白70的表达及其意义

被引:3
作者
郝玉曼
罗祖明
周东
机构
[1] 四川大学华西医院神经内科
关键词
缺血预处理; 缺血耐受; 脑缺血; 热休克蛋白;
D O I
暂无
中图分类号
R741 [神经病学];
学科分类号
摘要
目的 研究局灶脑缺血预处理对热休克蛋白 70 (HSP70 )表达和脑缺血耐受的影响。方法 SD大鼠随机分为 3组 :预缺血组、假手术组及对照组 ,前两组分别在 2小时大脑中动脉缺血 (MCAO)前 3天给予10分钟的预缺血或假手术 ,MCAO后 2 4小时处死 ,对照组给予两次相隔 3天的假手术 ,比较各组梗死体积及HSP70的表达。结果 预缺血组梗死体积较假手术组减少 5 2 5 4 % (P <0 0 1) ,HSP70表达高于假手术组及对照组 (P <0 0 1)。结论  10分钟大脑中动脉预缺血可有效诱导缺血耐受 ,增加HSP70表达。HSP70表达上调可能是局灶性脑缺血耐受产生的分子机制之一
引用
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页码:284 / 286
页数:3
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