氯吡格雷抵抗临床防治的研究进展

被引:8
作者
李建华
曹剑
范利
机构
[1] 解放军总医院南楼心内科
关键词
阿司匹林; 血小板聚集抑制剂; 急性冠状动脉综合征; 支架; 血栓形成;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
1002 ; 100201 ;
摘要
<正>阿司匹林联合氯吡格雷双联抗血小板治疗已经成为防治急性冠状动脉综合征(ACS)的基石。现已明确,双联抗血小板治疗能够有效抑制PCI术后患者支架内血栓的形成[1]。然而,尽管接受规范的双联抗血小板治疗,部分患者仍会出现反复的缺血事件[2-4]。氯吡格雷抵抗是导致患者抗血小板治疗不达标的重要原因之一。氯吡格雷抵抗的发生机制尚不明确,目前证实与相关基因多态性、药物相互作用、患者依从性、糖耐量异常、肥胖等因素相关[5-8]。近来,人们对氯吡
引用
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页码:1324 / 1326
页数:3
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