2016年银屑病临床研究进展回顾

被引:14
作者
付玉娟
郑敏
机构
[1] 浙江大学医学院附属第二医院皮肤科
关键词
D O I
暂无
中图分类号
R758.63 [牛皮癣(银屑病)];
学科分类号
100227 [皮肤病学];
摘要
<正>银屑病是一种以红斑鳞屑为典型临床表现的慢性复发性炎症性皮肤病。其确切的发病机制尚不明确,部分患者经传统治疗效果欠佳,生物制剂的出现为银屑病的治疗提供了更有效的方案,特别是靶向白细胞介素23/Th17/白细胞介素17轴的全人源性和人源化单克隆抗体在治疗中重度斑块状银屑病及银屑病性关节炎上取得了良好的疗效。
引用
收藏
页码:12 / 14
页数:3
相关论文
共 7 条
[1]
Discovery and characterization of COVA322; a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases[J] Michela Silacci;Wibke Lembke;Richard Woods;Isabella Attinger-Toller;Nadja Baenziger-Tobler;Sarah Batey;Roger Santimaria;Ulrike von der Bey;Susann Koenig-Friedrich;Wenjuan Zha;Bernd Schlereth;Mathias Locher;Julian Bertschinger;Dragan Grabulovski mAbs 2016,
[2]
Maintenance of Clinical Efficacy and Radiographic Benefit Through Two Years of Ustekinumab Therapy in Patients With Active Psoriatic Arthritis: Results From a Randomized; Placebo‐Controlled Phase III Trial[J] Arthur Kavanaugh;Lluís Puig;Alice B. Gottlieb;Christopher Ritchlin;Shu Li;Yuhua Wang;Alan M. Mendelsohn;Michael Song;Yaowei Zhu;Proton Rahman;Iain B. McInnes; Arthritis Care & Research 2015,
[3]
Tildrakizumab ( MK ‐3222); an anti‐interleukin‐23p19 monoclonal antibody; improves psoriasis in a phase IIb randomized placebo‐controlled trial[J] K. Papp;D. Tha?i;K. Reich;E. Riedl;R.G. Langley;J.G. Krueger;A.B. Gottlieb;H. Nakagawa;E.P. Bowman;A. Mehta;Q. Li;Y. Zhou;R. Shames Br J Dermatol 2015,
[4]
Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR; a randomized controlled trial[J] Diamant Tha?i;Andrew Blauvelt;Kristian Reich;Tsen-Fang Tsai;Francisco Vanaclocha;Külli Kingo;Michael Ziv;Andreas Pinter;Sophie Hugot;Ruquan You;Marina Milutinovic Journal of the American Academy of Dermatology 2015,
[5]
Ixekizumab for treatment of psoriasis[J] Beatrice Dyring-Andersen;Lone Skov;Claus Zachariae Expert Review of Clinical Immunology 2015,
[6]
Efficacy and safety of brodalumab in subpopulations of patients with difficult-to-treat moderate-to-severe plaque psoriasis[J] Kim Papp;Alan Menter;Bruce Strober;Greg Kricorian;Elizabeth H.Z. Thompson;Cassandra E. Milmont;Ajay Nirula;Paul Klekotka Journal of the American Academy of Dermatology 2015,
[7]
Brodalumab; an Anti-IL17RA Monoclonal Antibody; in Psoriatic Arthritis[J] Philip J. Mease;Mark C. Genovese;Maria W. Greenwald;Christopher T. Ritchlin;André D. Beaulieu;Atul Deodhar;Richard Newmark;JingYuan Feng;Ngozi Erondu;Ajay Nirula The New England Journal of Medicine 2014,