黄芪-苍术改善糖尿病肾病糖脂代谢的网络药理学研究

被引:30
作者
王鑫
吴巧敏
黄超颖
王箴仪
施敏
周逸钧
张美芳
陈洁文
机构
[1] 上海交通大学医学院附属第九人民医院临床营养科
关键词
黄芪-苍术; 糖尿病肾病; 糖脂代谢; 网络药理学;
D O I
10.16333/j.1001-6880.2019.12.005
中图分类号
R285 [中药药理学];
学科分类号
100806 [中药药理学];
摘要
为探讨黄芪-苍术改善糖尿病肾病糖脂代谢的作用机制。运用网络药理学方法,通过中药系统药理学数据库(TCMSP)筛选出黄芪、苍术的有效活性成分和作用靶点,再利用Drug Bank、Gene Cards、OMIM等数据库筛选出与糖尿病肾病相关的潜在作用靶点。采用Cytoscape 3. 6. 1软件和Metascape数据库构建活性成分-靶点网络图,利用KEGG和GO富集分析药物与糖脂代谢相关的信号通路。通过筛选得出黄芪和苍术有效活性成分29个,其中槲皮素、山奈酚、汉黄芩素、异鼠李素等成分可能是通过靶向PIK3CG、AKT1、MAPK1、IGF2等靶点,参与m TOR、胰岛素、脂肪细胞因子、Jak-STAT信号通路发挥调节糖尿病肾病糖脂代谢作用。综上,黄芪-苍术改善糖尿病肾病糖脂代谢存在多成分、多靶点和多重药理作用,为进一步研究治疗糖尿病肾病提供了线索。
引用
收藏
页码:2051 / 2057
页数:7
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