路优泰对抑郁大鼠脑内氨基酸水平的影响

被引:7
作者
杨培
李雪春
田晶辰
林龙飞
付京
张慧
倪健
机构
[1] 北京中医药大学中药学院
关键词
路优泰; 神经递质; 抑郁; 氨基酸;
D O I
暂无
中图分类号
R285.5 [中药实验药理];
学科分类号
100806 [中药药理学];
摘要
氨基酸神经递质系统是抑郁症发病机制研究中非常重要的一个部分,研究抗抑郁药物对氨基酸水平的影响有重要的意义。本课题采用了i TRAQ试剂衍生、同位素内标标记、液相色谱-串联质谱技术检测路优泰对抑郁大鼠脑内氨基酸水平影响,并采用SIMACA-P软件进行数据统计和分析。研究结果表明,路优泰通过调节脑内天门冬氨酸、牛磺酸、酌-氨基丁酸和谷氨酰胺水平实现其抗抑郁作用。
引用
收藏
页码:2174 / 2179
页数:6
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