子宫内膜VEGF、MVD表达和子宫腺肌病、痛经、月经过多的关系研究

被引：7

作者：

刘燕 ^{[1
]}

康佳丽 ^{[2
]}

王小霞 ^{[2
]}

余佳 ^{[2
]}

机构：

[1] 江西省赣州市人民医院妇产科

[2] 广州医学院附属广州市第一人民医院妇产科

来源：

临床和实验医学杂志 | 2011年 / 10卷 / 01期

关键词：

子宫腺肌病; 血管内皮生长因子; 微血管密度; 痛经; 月经过多;

D O I：

暂无

中图分类号：

R711.5 [女性生殖器功能性疾病]; R711.71 [子宫内膜异位症];

学科分类号：

摘要：

目的探讨血管内皮生长因子(VEGF)、微血管密度(MVD)在子宫腺肌病(AM)中的表达及意义,探讨其表达与AM的发生与痛经、月经过多的相关性。方法采用SP免疫组织化学方法检测51例AM患者在位及异位子宫内膜及40例正常子宫内膜组织中VEGF的表达及MVD值。结果 VEGF、MVD在AM异位内膜中的表达均明显高于正常内膜及在位内膜(P<0.05);VEGF与MVD分别呈正相关(P<0.05);VEGF、MVD在AM在位内膜组中的表达与AM患者月经过多呈正相关,与痛经无相关性。结论 VEGF、MVD在AM异位、在位内膜中的高表达,提示局部血供丰富和新生血管形成与AM的发病及月经过多有关。

引用

页码：14 / 15

页数：2

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