慢性心力衰竭患者血浆正五聚蛋白3水平的临床观察

被引：6

作者：

李涛

张菲斐

魏经汉

机构：

[1] 郑州大学第一附属医院心内科

来源：

临床荟萃 | 2010年 / 25卷 / 05期

关键词：

心力衰竭,充血性; 正五聚蛋白3; 酶联免疫吸附测定法;

D O I：

暂无

中图分类号：

R541.61 [];

学科分类号：

1002 ; 100201 ;

摘要：

目的通过检测慢性心力衰竭(chronic heart failure,CHF)患者和非心力衰竭对照者血浆正五聚蛋白3(pentraxin 3,PTX3)水平,探讨血浆PTX3在CHF中的临床意义。方法按Framinghan诊断标准入选CHF患组66例,非心力衰竭对照组20例。采用酶联免疫吸附测定法检测两组血浆PTX3水平。结果CHF组血浆PTX3水平明显高于非心力竭衰对照组,(3.3±1.4)μg/L vs(1.8±0.6)μg/L(P<0.01);CHF组血浆PTX3水平随纽约心脏病学会(NYHA)心功能分级增加而上升(P<0.01);CHF患者血浆PTX3水平与左心室舒张末期内径(LVEDD)呈正相关(r=0.431,P<0.01),与左心室射血分数(LVEF)呈负相关(r=-0.452,P<0.01)。结论血浆PTX3水平高低反映慢性心力衰竭的炎症程度,并随心功能的恶化而升高。

引用

页码：380 / 382

页数：3

共 7 条

[1]

Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure[J] . Satoshi Suzuki,Yasuchika Takeishi,Takeshi Niizeki,Yo Koyama,Tatsuro Kitahara,Toshiki Sasaki,Mina Sagara,Isao Kubota.American Heart Journal . 2008 (1)

[2] Inflammation and long-term mortality in acute congestive heart failure [J].

Mueller, C ;

Laule-Kilian, K ;

Christ, A ;

Brunner-La Rocca, HP ;

Perruchoud, AP .

AMERICAN HEART JOURNAL, 2006, 151 (04) :845-850

[3] Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction [J].

Latini, R ;

Maggioni, AP ;

Peri, G ;

Gonzini, L ;

Lucci, D ;

Mocarelli, P ;

Vago, L ;

Pasqualini, F ;

Signorini, S ;

Soldateschi, D ;

Tarli, L ;

Schweiger, C ;

Fresco, C ;

Cecere, R ;

Tognoni, G ;

Mantovani, A .

CIRCULATION, 2004, 110 (16) :2349-2354

[4] Independent prognostic value of elevated high-sensitivity C-reactive protein in chronic heart failure [J].

Yin, WH ;

Chen, JW ;

Jen, HL ;

Chiang, MC ;

Huang, WP ;

Feng, AN ;

Young, MS ;

Lin, SJ .

AMERICAN HEART JOURNAL, 2004, 147 (05) :931-938

[5] Prognostic value of serum cytokines in patients with congestive heart failure [J].

Orús, J ;

Roig, E ;

Perez-Villa, F ;

Paré, C ;

Azqueta, M ;

Filella, X ;

Heras, M ;

Sanz, G .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2000, 19 (05) :419-425

[6] Increased expression of interleukin-1 beta and monocyte chemotactic and activating factor monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload [J].

Shioi, T ;

Matsumori, A ;

Kihara, Y ;

Inoko, M ;

Ono, K ;

Iwanaga, Y ;

Yamada, T ;

Iwasaki, A ;

Matsushima, K ;

Sasayama, S .

CIRCULATION RESEARCH, 1997, 81 (05) :664-671

[7]

Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)[J] . Guillermo Torre-Amione,Samir Kapadia,Claude Benedict,Hakan Oral,James B. Young,Douglas L. Mann.Journal of the American College of Cardiology . 1996 (5)

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