1400W对成年大鼠脑缺血后海马神经元再生的影响

被引：4

作者：

王玮

孙勇军

奚涛

朱东亚

机构：

[1] 中国药科大学新药研究中心

[2] 中国药科大学生物制药学院

[3] 中国药科大学新药研究中心南京

[4] 南京

[5] 南京医科大学药学院

来源：

中国药理学通报 | 2004年 / 01期

关键词：

1400W; 诱生型一氧化氮合酶; 神经元再生; 脑缺血;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的　研究脑缺血对海马齿状回神经元再生的刺激作用 ,以及iNOS抑制剂对缺血诱发的神经元再生的影响。方法　血管内栓线法阻塞大脑中动脉 1 5h然后再灌注制备再灌性局灶脑缺血模型。腹腔注射iNOS抑制剂 14 0 0W(5mg·kg-1)。BrdU参入法测定海马齿状回的细胞扩增。于再灌注后 2 4h测定海马iNOS活性及NO水平。结果　在脑缺血后d 8缺血侧海马齿状回的BrdU阳性细胞数比对照侧多大约 5倍 ,14 0 0W抑制iNOS活性和降低NO水平 ,同时抑制脑缺血诱发的海马齿状回神经细胞扩增。结论　iNOS是脑缺血诱发海马齿状回神经元再生的重要分子 ,激活iNOS可能是促进脑缺血损伤功能修复的治疗策略之一。

引用

页码：33 / 37

页数：5

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