缺血再灌注对鼠脑血管内皮生长因子表达的影响

被引：4

作者：

程敬君

匡培根

机构：

[1] 军事医学科学院附属医院内二科!北京

[2] 解放军总医院神经介质室!北京

来源：

中国神经免疫学和神经病学杂志 | 2001年 / 01期

关键词：

脑缺血再灌注; 血管内皮生长因子; 免疫组织化学;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

摘要：

目的　了解血管内皮生长因子 (VEGF)在一过性全脑缺血再灌注鼠脑表达的动态变化。方法　采用Pulisnelli改良法四血管堵塞全脑缺血再灌注模型 ,用免疫组织化学方法观察了全缺血 15min再灌注 2h～ 14d时 ,VEGF表达的动态变化。结果　全脑缺血 15min再灌注 6hVEGF即可在大脑皮层、纹状体及丘脑等区域的血管内皮细胞表达 ,1d达高峰 ,一直持续到缺血后再灌注 3d。结论　脑缺血后再灌注可上调VEGF在大脑皮质、纹状体及丘脑等区域内皮细胞的表达 ,VEGF可能通过促进血管内皮细胞生长对缺血性神经元损伤起一定的作用。

引用

页码：3 / 4+8 +8

页数：3

共 8 条

[1]

Hypoxiz is a strong inducer of vascular endothelial growth factor mRNA expression in the heart. Ladoux Aa,Frelin C. Biochemical and Biophysical Research Communications . 1993

[2]

The four-vessel occlusion rat model: method for complete occlusion of vertebral and control of collateral circulation. Pulsinell WA,Buchan AM. Stroke . 1988

[3]

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. Connolly DT,Heuvelman DM,Nelson R,et al. The Journal of Clinical Investigation . 1989

[4]

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Breier G,Albrecht U,Sterer S,et al. Development Cambridge England . 1992

[5]

Hypoxin-induced paracrine regulation by vascular endothelial growth factor receptor expression. Brogi E,Schaheman G,Wu TG,et al. The Journal of Clinical Investigation . 1996

[6]

Upregulation of vascular endothelial growth factor expression induced by myocardial ischemia Implications for coronary angiogenesis. Banai S,Shweiki D,Pinson A. Cardiovascular Research . 1994

[7]

GROWTH FACTORS[P]. HEARN MILTON THOMAS WILLIAM;BERTOLINI JOSEPH;GUTHRIDGE MARK ANDREW.澳大利亚专利:AU611614B2,1991-06-13

[8]

Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissue. Monacci Wt,Merrill MJ,Oldfield EH. American Journal of Physiology . 1993

← 1 →