硫化氢和动脉粥样硬化

被引：2

作者：

赵战芝

姜志胜

机构：

[1] 南华大学心血管病研究所暨动脉硬化学湖南省重点实验室

来源：

中国动脉硬化杂志 | 2009年 / 17卷 / 12期

基金：

湖南省自然科学基金;

关键词：

硫化氢; 动脉粥样硬化; 气体信号分子;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

摘要：

硫化氢以其毒性作用为人所知几百年,现在被誉为第三个气体信号分子。硫化氢主要在胱硫醚-β-合成酶和胱硫醚-γ-裂解酶作用下酶性产生,具有舒张血管、调节血压、抑制血管平滑肌细胞增殖和低密度脂蛋白氧化修饰等功能。以载脂蛋白E基因敲除小鼠为模型的一项研究显示,抑制内源性硫化氢产生将促进主动脉病变形成,而补充外源性硫化氢可抑制主动脉病变形成。这些数据表明硫化氢是动脉粥样硬化发生发展的新调节物质。文章就硫化氢的抗动脉粥样硬化效应做一综述。

引用

页码：1038 / 1040+1044 +1044

页数：4

共 10 条

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