胰岛B细胞脂性凋亡研究进展

Decreasing IRS-2 expression in pancreatic β-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression[J] . Melissa K. Lingohr,Lorna M. Dickson,Christian E. Wrede,Isabelle Briaud,Jill F. McCuaig,Martin G. Myers,Christopher J. Rhodes. &nbspMolecular and Cellular Endocrinology . 2003 (1)

The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits β-cell apoptosis in vitro[J] .  &nbspBiochemical and Biophysical Research Communications . 2005 (2)

Contribution of free fatty acids to impairment of insulin secretion and action. mechanism of beta-cell lipotoxicity. Girard J. Med Sci (Paris) . 2005

Decreasing IRS-2expression in pancreatic beta-cells(INS-1)promotes apoptosis,which can be compensated for by introduction of IRS-4 expression. Lingohr MK,Dickson LM,Wrede CE,et al. Molecular and Cellular Endocrinology . 2003

Activation of peroxisome pro-liferator-activated receptor-γby rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol3-kinase dependent pathway. Lin CY,Gurlo T,Haataja L,et al. The Journal of Clinical Endocrinology . 2005

Evidence thatincreased 12-lipoxygenase expression i mpairs pancreatic betacell function and viability. Prasad KM,Thi mmalapura PR,Woode EA,et al. Biochemical and Biophysical Research Communications . 2003

RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. Johnson,JD,Han,Z,Otani,K,Ye,H,Zhang,H,Wu,H,Horikawa,Y,Misler,S,Bell,GI,Polonsky,KS. Journal of Biological Chemistry . 2004

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: Possible role of oxidative stress[J] . Salvatore Piro,Marcello Anello,Cinzia Di Pietro,Maria Natalia Lizzio,Giovanni Patan[egrave],Agata Maria Rabuazzo,Riccardo Vigneri,Michele Purrello,Francesco Purrello. &nbspMetabolism . 2002 (10)

Decreasing IRS-2 expression in pancreatic β-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression[J] . Melissa K. Lingohr,Lorna M. Dickson,Christian E. Wrede,Isabelle Briaud,Jill F. McCuaig,Martin G. Myers,Christopher J. Rhodes. &nbspMolecular and Cellular Endocrinology . 2003 (1)

The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits β-cell apoptosis in vitro[J] .  &nbspBiochemical and Biophysical Research Communications . 2005 (2)

Contribution of free fatty acids to impairment of insulin secretion and action. mechanism of beta-cell lipotoxicity. Girard J. Med Sci (Paris) . 2005

Decreasing IRS-2expression in pancreatic beta-cells(INS-1)promotes apoptosis,which can be compensated for by introduction of IRS-4 expression. Lingohr MK,Dickson LM,Wrede CE,et al. Molecular and Cellular Endocrinology . 2003

Activation of peroxisome pro-liferator-activated receptor-γby rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol3-kinase dependent pathway. Lin CY,Gurlo T,Haataja L,et al. The Journal of Clinical Endocrinology . 2005

Evidence thatincreased 12-lipoxygenase expression i mpairs pancreatic betacell function and viability. Prasad KM,Thi mmalapura PR,Woode EA,et al. Biochemical and Biophysical Research Communications . 2003

RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. Johnson,JD,Han,Z,Otani,K,Ye,H,Zhang,H,Wu,H,Horikawa,Y,Misler,S,Bell,GI,Polonsky,KS. Journal of Biological Chemistry . 2004

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: Possible role of oxidative stress[J] . Salvatore Piro,Marcello Anello,Cinzia Di Pietro,Maria Natalia Lizzio,Giovanni Patan[egrave],Agata Maria Rabuazzo,Riccardo Vigneri,Michele Purrello,Francesco Purrello. &nbspMetabolism . 2002 (10)