梗阻性黄疸对肠黏膜屏障的影响

被引:12
作者
葛存锦 [1 ,2 ]
李闻 [1 ]
机构
[1] 解放军总医院消化科
[2] 南开大学医学院
关键词
肠黏膜屏障; 肠黏膜通透性; 梗阻性黄疸; 内毒素血症;
D O I
暂无
中图分类号
R575 [肝及胆疾病];
学科分类号
100201 [内科学];
摘要
肠黏膜屏障包括机械屏障、免疫屏障、生物屏障和化学屏障,四者共同维持肠黏膜的正常防御功能。梗阻性黄疸患者引起肠黏膜屏障损伤,导致细菌移位及内毒素血症,后者又加重屏障功能障碍。本文主要就梗阻性黄疸对肠黏膜屏障损伤的机制作一综述。
引用
收藏
页码:960 / 963
页数:4
相关论文
共 18 条
[1]
Intestinal epithelial cell proliferation, apoptosis and expression of tight junction proteins in patients with obstructive jaundice [J].
Assimakopoulos, Stelios F. ;
Tsamandas, Athanassios C. ;
Louvros, Emanuel ;
Vagianos, Constantine E. ;
Nikolopoulou, Vassiliki N. ;
Thomopoulos, Konstantinos C. ;
Charonis, Aristidis ;
Scopa, Chrisoula D. .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2011, 41 (02) :117-125
[2]
Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients [J].
Wang, Na ;
Yu, Huiling ;
Ma, Junji ;
Wu, Wenxin ;
Zhao, Dongqiang ;
Shi, Xiaodong ;
Tian, Hui ;
Jiang, Huiqing .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2010, 45 (02) :191-199
[3]
Obstructive jaundice promotes intestinal-barrier dysfunction and bacterial translocation: experimental study [J].
Abdeldayem, Hesham ;
Ghoneim, Enas ;
Refaei, Ahmad Ahmad-El ;
Abou-Gabal, Ashraf .
HEPATOLOGY INTERNATIONAL, 2007, 1 (04) :444-448
[4]
Effect of Antioxidant Treatments on the Gut–Liver Axis Oxidative Status and Function in Bile Duct-Ligated Rats.[J].Stelios F. Assimakopoulos;Ioannis Maroulis;Nikolaos Patsoukis;Konstantinos Vagenas;Chrisoula D. Scopa;Christos D. Georgiou;Constantine E. Vagianos.World Journal of Surgery.2007, 10
[5]
Bombesin and neurotensin reduce endotoxemia, intestinal oxidative stress, and apoptosis in experimental obstructive jaundice [J].
Assimakopoulos, SF ;
Scopa, CD ;
Zervoudakis, G ;
Mylonas, PG ;
Georgiou, C ;
Nikolopoulou, V ;
Vagianos, CE .
ANNALS OF SURGERY, 2005, 241 (01) :159-167
[6]
Taurodeoxycholate stimulates intestinal cell proliferation and protects against apoptotic cell death through activation of NF-κB [J].
Toledo, A ;
Yamaguchi, J ;
Wang, JY ;
Bass, BL ;
Turner, DJ ;
Strauch, ED .
DIGESTIVE DISEASES AND SCIENCES, 2004, 49 (10) :1664-1671
[7]
Regulation of IgA synthesis at mucosal surfaces [J].
Fagarasan, S ;
Honjo, T .
CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (03) :277-283
[8]
Internal biliary drainage improves decreased number of gut mucosal T lymphocytes and MAdCAM-1 expression in jaundiced rats [J].
Sano, T ;
Ajiki, T ;
Takeyama, Y ;
Kuroda, Y .
SURGERY, 2004, 136 (03) :693-699
[9]
Taurodeoxycholate increases intestinal epithelial cell proliferation through c-myc expression [J].
Yamaguchi, J ;
Toledo, A ;
Bass, BL ;
Celeste, FA ;
Rao, JN ;
Wang, JY ;
Strauch, ED .
SURGERY, 2004, 135 (02) :215-221
[10]
Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells [J].
Kojima, K ;
Musch, MW ;
Ren, HY ;
Boone, DL ;
Hendrickson, BA ;
Ma, A ;
Chang, EB .
GASTROENTEROLOGY, 2003, 124 (05) :1395-1407