肾癌组织中微血管密度、DNA含量检测的临床意义

被引:8
作者
贾瑞鹏
马庆铮
刘军
程继义
许纯孝
王万忠
杜德利
姜玉菲
机构
[1] 南京医科大学附属南京第一医院泌尿外科
[2] 山东省立医院泌尿外科
[3] 山东省立医院病理科
[4] 山东省立医院妇产科 江苏南京
[5] 江苏南京
[6] 山东济南
关键词
肾癌; 微血管密度; 脱氧核糖核酸;
D O I
暂无
中图分类号
R737.11 [肾、肾盂肿瘤];
学科分类号
100214 ;
摘要
目的:探讨肾癌组织内微血管密度(IMD)、DNA含量的临床意义。方法:采用免疫组织化学(LSAB法)方法及图像分析技术对76例肾癌患者手术切除的标本进行IMD和DNA含量测定,并分析其与预后间的关系。结果:不同肾癌细胞类型、病理分级之间IMD值比较差异无显著性(P>0.05);随临床分期的升高,IMD增高(P<0.05)。转移组IMD值明显高于非转移组(P<0.01);随访5年内死亡者IMD、DNA含量均高于存活5年以上者(P<0.05)。Spearman相关分析研究表明:IMD与DNA蛋白含量具正相关性。结论:IMD值的变化与肾癌恶性程度相关,较高的IMD和DNA含量常提示患者预后较差。
引用
收藏
页码:261 / 263+295 +295
页数:4
相关论文
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