退行性钙化性主动脉瓣膜病的病理组织学分析

被引：10

作者：

尹彤 ^{[1
]}

王士雯 ^{[1
]}

高磊 ^{[1
]}

李泱 ^{[1
]}

王红月 ^{[2
]}

刘蕾 ^{[2
]}

赵玉生 ^{[1
]}

机构：

[1] 解放军总医院老年心血管病研究所

[2] 中国医学科学院中国协和医科大学阜外心血管病医院病理科

来源：

中华老年多器官疾病杂志 | 2005年 / 04期

关键词：

退行性钙化性瓣膜病; 主动脉瓣膜; 病理组织学分析;

D O I：

暂无

中图分类号：

R542.5 [心瓣膜疾病];

学科分类号：

1002 ; 100201 ;

摘要：

目的分析退行性钙化性主动脉瓣膜病(DCAVD)不同病变阶段的病理组织学特征。方法选择尸检和经外科手术的成人主动脉瓣膜标本共55例,利用组织学和免疫组织化学染色方法,对瓣膜内各种物质和细胞的表达情况进行分析。回顾各例心血管危险因素有关的临床记录。结果不同程度主动脉瓣膜病变均以瓣膜基底部增厚明显,增厚区病灶及附近的纤维层内蛋白质,脂肪和钙盐聚集。免疫组化染色示,不同程度病变中,CD68阳性的单核巨噬细胞浸润,偶尔可见T细胞;还可见由CD31阳性的内皮细胞围绕而成的新生毛细血管结构,以及骨母细胞标记物OPN表达,上述标记物随病变程度加重而表达数量增加。心血管疾病危险因素,如吸烟史、高脂血症、高血压、冠心病,在重度病变中的发生率显著高于轻中度病变。结论 DCAVD的病理组织学特征与动脉粥样硬化具有相似之处,这些特征包括瓣膜内脂质、蛋白质和钙盐沉积,单核巨噬细胞浸润,新生毛细血管增生以及骨母细胞形成。

引用

页码：277 / 281

页数：5

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