氧化型脂蛋白(a)对鼠腹腔巨噬细胞增殖的影响

被引：5

作者：

张春妮

庄一义

吉维民

刘小转

强红娟

机构：

[1] 南京军区南京总医院全军医学检验中心!南京

[2] 宝应县人民医院检验科

来源：

中国动脉硬化杂志 | 2000年 / 04期

关键词：

脂蛋白; 巨噬细胞,腹腔; 增殖; 动脉粥样硬化;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

为探讨氧化型脂蛋白 (a)对巨噬细胞增殖的影响 ,采用细胞计数和MTT掺入观察比较天然型脂蛋白(a)、氧化型脂蛋白 (a)和丙二醛修饰脂蛋白 (a)对培养的鼠腹腔巨噬细胞增殖的影响。结果发现 ,氧化型脂蛋白 (a)在蛋白浓度为 2 .5～ 40mg/L时刺激巨噬细胞增殖 ,蛋白浓度为 40mg/L时巨噬细胞数为对照组的 1.5倍 (P <0 .0 5 )。而天然型脂蛋白 (a)和丙二醛修饰脂蛋白 (a)对巨噬细胞增殖无影响。结果提示 ,氧化型脂蛋白 (a)可能通过促进巨噬细胞增殖加速动脉粥样硬化的发展。

引用

页码：305 / 307

页数：3

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