2型糖尿病患者血清PCSK9与动脉粥样硬化指标的相关性分析

被引：11

作者：

茅国芳 ^{[1
,2
]}

王坤林 ^{[2
]}

符金香 ^{[2
]}

付真真 ^{[2
]}

周莹 ^{[2
]}

龚颖芸 ^{[2
]}

周红文 ^{[2
]}

机构：

[1] 江苏省人民医院盛泽分院内分泌科

[2] 南京医科大学第一附属医院内分泌科

来源：

南京医科大学学报(自然科学版) | 2016年 / 36卷 / 01期

关键词：

前蛋白转化酶枯草溶菌素9; 颈动脉内膜中层厚度; 动脉粥样硬化; 2型糖尿病;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

目的:研究2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin/kexin 9,PCSK9)与动脉粥样硬化(atherosclerosis,AS)指标的相关性。方法 :对351例T2DM患者进行病史采集、颈部及下肢血管彩色多普勒检查,测定其PCSK9水平。结果:T2DM合并AS组患者的血清PCSK9水平高于T2DM无AS组(P<0.05),血清PCSK9水平与T2DM患者的颈总动脉内中膜厚度(carotid artery intima-media thickness,CIMT)呈正相关(P<0.01),与右侧颈总动脉(RCCA)内径、RCCA峰值/次峰值(PI)、右侧颈内动脉(RICA)PI、左侧颈总动脉(LCCA)PI、左侧颈内动脉(LICA)PI、RICA阻力指数(RI)、LCCA RI等颈动脉粥样硬化相关性指标呈正相关(P<0.05),而与RCCAVmax、RCCA Vmin、RCCA Tamx等指标呈负相关(P<0.05)。结论 :T2DM患者血清PCSK9水平与评估AS程度的指标密切相关,可能成为临床预测及评估T2DM患者AS相关大血管疾病发生风险的指标。

引用

页码：46 / 50

页数：5

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