胃肠道菌群与肿瘤发生的关系

被引：20

作者：

董开芯 ^{[1
]}

王正强 ^{[2
]}

于新娟 ^{[1
]}

王莉莉 ^{[1
]}

董全江 ^{[1
]}

机构：

[1] 青岛大学医学院附属青岛市市立医院消化科及中心实验室

[2] 青岛市市立医院检验科

来源：

现代生物医学进展 | 2014年 / 14卷 / 11期

关键词：

胃肠道菌群; 肿瘤; 致病机制;

D O I：

10.13241/j.cnki.pmb.2014.11.051

中图分类号：

R57 [消化系及腹部疾病]; R730.2 [肿瘤病理学、病因学];

学科分类号：

100201 [内科学]; 100214 [肿瘤学];

摘要：

人体的胃肠道菌群构成一个庞大、复杂的微生态系统,并且随着年龄的增长而发生动态变化,成年后菌群的结构达到动态平衡。胃肠道菌群具有参与物质代谢、促进机体免疫系统的发育和抑制病原菌定植等生理作用。菌群失调会导致各种疾病的发生,如肠易激综合征、炎症性肠病、肥胖症、1型糖尿病、肠道恶性肿瘤等。本文就胃肠道菌群与肿瘤发生发展关系的最新研究作一综述,并根据最新提出的Alpha-Bug学说和driver-passenger学说,论述了肠道菌群促进大肠癌发生的机制。为阐明胃肠道肿瘤的发生机制提供新的思路。

引用

页码：2196 / 2200

页数：5

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