5-HTTLPR与抑郁相关性的研究动态

被引：4

作者：

张俊先 ^{[1
,2
]}

陈杰 ^{[2
]}

李新影 ^{[2
]}

机构：

[1] 中国科学院研究生院

[2] 中国科学院心理研究所心理健康重点实验室

来源：

心理科学 | 2012年 / 35卷 / 01期

关键词：

5-HTTLPR; 抑郁; 交互作用; 生活事件; 机制;

D O I：

10.16719/j.cnki.1671-6981.2012.01.039

中图分类号：

B842.6 [情绪与情感];

学科分类号：

040201 ;

摘要：

本文对5-HTTLPR与抑郁关系的相关研究进行了综述。5-HTTLPR基因型并不直接影响抑郁的发生,而是通过基因与环境交互作用影响的。携带有S等位基因的个体暴露于较多的负性生活事件时,更易发生抑郁。另外,5-HTTLPR还与CYP2C9、BDNF等基因存在交互作用。研究发现5-HTTLPR对抑郁作用的机制可能有两条。首先,和基因型为L/L的个体相比,携带有S等位基因的个体的杏仁核脑区的活动增强,而前额叶-杏仁核神经环路的耦合相对较弱。其次,携带有S等位基因的个体在应激条件下HPA轴活性更强,有更高的皮质醇含量,进而更容易抑郁。总结前人的研究发现,5-HTTLPR通过影响情绪加工的脑区以及参与应激反应的HPA轴活性而使个体具有不同的易感性,有较高易感性的个体(携带S等位基因)在较高的应激条件下或者其他易感基因型存在时就会发生抑郁。

引用

页码：226 / 232

页数：7

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