Th17细胞及IL-17在非小细胞肺癌患者外周血的表达及临床意义

被引:6
作者
王胜 [1 ]
张蕊 [1 ]
王俊凤 [1 ]
赵辉 [2 ]
机构
[1] 吉林省肿瘤医院内一科
[2] 吉林省肿瘤医院胸外一科
关键词
非小细胞肺癌; 辅助性T细胞17; 白细胞介素17;
D O I
暂无
中图分类号
R734.2 [肺肿瘤];
学科分类号
摘要
目的探讨辅助性T细胞17(Th17)和白细胞介素17(IL-17)在非小细胞肺癌(NSCLC)患者外周血中的表达和临床意义。方法选取原发性NSCLC患者40例为观察组,健康志愿者40例为对照组,采用流式细胞仪检测2组外周血Th17细胞水平,采用酶联免疫吸附法(ELISA)检测血清IL-17水平。比较2组外周血Th17细胞及IL-17水平,分析观察组患者外周围血Th17细胞及IL-17水平与临床病理特征的关系。结果观察组外周血中Th17细胞和IL-17水平明显高于对照组(P<0.01);鳞状细胞癌患者外周血Th17细胞水平和IL-17表达高于腺癌患者,且ⅢⅣ期患者明显高于ⅠⅡ期患者,差异均有统计学意义(P<0.01)。结论在NSCLC的发生发展的过程中,Th17细胞及细胞因子IL-17可能发挥一定作用。
引用
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页码:34 / 36
页数:3
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