肿瘤相关巨噬细胞在乳腺癌中的作用及研究进展

被引：8

作者：

张颢

赵娟

于希忠

机构：

[1] 南京中医药大学

来源：

医学理论与实践 | 2020年 / 33卷 / 18期

关键词：

肿瘤相关巨噬细胞; 肿瘤微环境; 乳腺癌; 靶向治疗;

D O I：

10.19381/j.issn.1001-7585.2020.18.011

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

100214 [肿瘤学];

摘要：

乳腺癌是世界范围内女性发病率最高的恶性肿瘤之一。肿瘤相关巨噬细胞(TAMs)是肿瘤微环境中重要的基质细胞,与乳腺癌预后呈负相关。TAMs具有高度可塑性,在不同因子刺激下可极化为经活化型巨噬细胞(M1型)或选择性活化型巨噬细胞(M2型)。目前研究认为,TAMs通常具有M2型巨噬细胞表型,在乳腺癌生长、浸润转移、免疫抑制、耐药中发挥了重要作用。本文主要对TAMs在乳腺癌中作用分子机制及靶向TAMs的治疗策略进行综述。

引用

页码：2992 / 2994

页数：3

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