瘦素对自发性高血压大鼠血管平滑肌细胞增殖的影响

被引：18

作者：

晋学庆

吴可贵

机构：

[1] 福建医科大学附属第一医院心内科

[2] 福建省高血压研究所

[3] 福建省高血压研究所福建福州

[4] 福建福州

来源：

高血压杂志 | 2002年 / 02期

关键词：

Leptin; OBRb; 血管平滑肌; 细胞; 自发性高血压大鼠; 增殖;

D O I：

10.16439/j.cnki.1673-7245.2002.02.015

中图分类号：

R544.1 [高血压];

学科分类号：

1002 ; 100201 ;

摘要：

目的　探讨leptin对自发性高血压大鼠血管平滑肌细胞的增殖影响 ,并研究leptinb型受体在VSMC中的表达。方法　本文主要采用培养的自发性高血压大鼠 (SHR)血管平滑肌细胞 (VSMC) ,研究Leptin受体b(OB Rb)的mRNA的表达 ,以及对平滑肌细胞增殖的影响。结果　OB Rb的mRNA仅在SHR大鼠的平滑肌细胞表达 ,而没有在正常对照大鼠 (WKY)的平滑肌细胞中表达。Leptin仅仅可以刺激SHR大鼠VSMC的DNA合成率的增加 ,而对WKY大鼠的VSMC则无作用。同样 ,Leptin对VSMC细胞增殖的作用 ,也仅仅在SHR大鼠可以发现 ,而WKY大鼠则没有。结论　上述研究的结果显示 ;高血压时 ,Leptin是一种对血管平滑肌细胞的增殖因子 ,也许在高血压的发生、发展过程中起重要的作用。

引用

页码：50 / 53+1

页数：5

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