前列腺素E2对成骨细胞OPGmRNA的调节

被引：2

作者：

吴小涛

张晔

机构：

[1] 东南大学附属中大医院骨科

[2] 东南大学附属中大医院骨科江苏南京

[3] 江苏南京

来源：

铁道医学 | 2001年 / 06期

关键词：

前列腺素E2; 成骨细胞; 破骨细胞;

D O I：

暂无

中图分类号：

R680.2 [];

学科分类号：

1002 ; 100210 ;

摘要：

目的　研究前列腺素E2 (PGE2 )对成骨细胞OPG基因表达的调节 ,探讨PGE2 引发骨吸收的机制。方法　体外培养大鼠成骨细胞 ,分别在不同时间、给予不同剂量PGE2 进行干预试验 ,提取总RNA进行半定量逆转录PCR分析 ,检测OPGmRNA水平的改变。结果　PGE2 可以抑制OPG基因的表达 ,其作用强度随时间、剂量而改变。结论　PGE2 调节骨代谢、增加骨吸收的作用 ,与其下调成骨细胞OPG基因表达 ,诱导破骨细胞形成及功能有关。

引用

页码：356 / 358

页数：3

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