一组人工合成抗菌肽的研究

被引：19

作者：

李国栋

钱承军

陆敏

孙睿华

黄青山

黄芳

机构：

[1] 上海高科联合生物技术研发有限公司

来源：

微生物学报 | 2006年 / 03期

关键词：

抗菌肽; 最小抑菌浓度; 多肽合成;

D O I：

10.13343/j.cnki.wsxb.2006.03.033

中图分类号：

TQ464.7 [氨基酸、肽、蛋白质];

学科分类号：

摘要：

Cecropin A1是一种从惜古比天蚕(Hyalophora cecropia)中提取的由37个氨基酸组成的一种α-螺旋抗菌肽,其杀菌活性较弱。本文采用了cecropin A1的N端1-8序列KWKLFKKI,另加一段标准的α-螺旋结构序列,然后用一个铰链结构GIG相连,合成了15条抗菌肽。经过试验证明部分含有核心标准螺旋结构的序列,对革兰氏阳性菌和阴性菌的最小抑菌浓度仅是原有cecropin A1抗菌肽的1/100左右。该类抗菌肽有希望进一步开发为新的抗感染药物。该类抗菌肽已经申请专利,专利号为PCT/CN 03/00522。

引用

页码：496 / 499

页数：4

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