活体血栓形成机理研究进展

被引：10

作者：

杨力

吕永钢

机构：

[1] 重庆大学生物工程学院国家“计划”基地

来源：

医用生物力学 | 2009年 / 24卷 / 06期

关键词：

血栓; 机理; 溶栓药物; 血栓形成; 血小板聚集; 剪切力;

D O I：

10.16156/j.1004-7220.2009.06.001

中图分类号：

R543 [血管疾病];

学科分类号：

1002 ; 100201 ;

摘要：

活体血管壁损伤和损坏引起血栓的形成机制很复杂,涉及到血液和血管性质及局部的血液流动等诸多因素。本文论述了活体血栓形成的研究意义、内容、进展及其相应的基本理论与实验研究方法,重点评述了信号转导和血液动力学在活体血栓形成中的重要作用,分析了活体动物模型中的难点,并归纳了该领域内若干可供探索的途径和新方向。

引用

页码：401 / 407

页数：7

共 17 条

[1] 血栓形成机理及溶血栓药物的研究进展 [J].

鲁艳莉 ;

宁喜斌 .

食品研究与开发, 2006, (01) :169-172

[2] 血栓溶解治疗的进展 [J].

陈灏珠 .

国外医学(内科学分册), 1991, (02) :50-54

[3] Numerical investigation of the non-Newtonian blood flow in a bifurcation model with a non-planar branch [J].

Chen, J ;

Lu, XY .

JOURNAL OF BIOMECHANICS, 2004, 37 (12) :1899-1911

[4]

Pulmonary Embolism: What have We Learned Since Virchow?[J] . James E. Dalen.Chest . 2002 (4)

[5]

New Model for in Vivo Quantification of Microvascular Embolization, Thrombus Formation, and Recanalization in Composite Flaps[J] . Journal of Surgical Research . 2002 (1)

[6] Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation [J].

Ruggeri, ZM .

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2001, 14 (02) :257-279

[7]

Effect of glycoprotein IIb/IIIa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularisation: the GUSTO IV-ACS randomised trial[J] . The Lancet . 2001 (9272)

[8]

Deep Venous Thrombosis and Pulmonary Embolus after Face Lift: A Study of Incidence and Prophylaxis[J] . John F. Reinisch,Stephen D. Bresnick,John W. T. Walker,Ronald F. Rosso.Plastic and Reconstructive Surgery . 2001 (6)

[9]

Oral Platelet IIb/IIIa Inhibitors: From Attractive Theory to Clinical Failures[J] . Paul A. Gurbel,Victor L. Serebruany.Journal of Thrombosis and Thrombolysis . 2000 (3)

[10]

Fluid Mechanics of Vascular Systems, Diseases, and Thrombosis[J] . David M. Wootton,David N. Ku.Annual Review of Biomedical Engineering . 1999

← 1 2 →