肿瘤干细胞的生物学特性及其研究进展

被引：8

作者：

关心 ^{[1
]}

陆智祥 ^{[2
]}

杨同华 ^{[1
,2
]}

机构：

[1] 昆明理工大学附属医院

[2] 云南省第一人民医院血液科

来源：

生命科学 | 2014年 / 26卷 / 02期

关键词：

肿瘤干细胞; 生物学特性; 表面标志; 微环境; 耐药;

D O I：

10.13376/j.cbls/2014029

中图分类号：

Q279 [癌细胞生物学];

学科分类号：

071011 [生物物理学];

摘要：

肿瘤干细胞(cancer stem cells,CSC)是肿瘤组织中存在的一类干细胞,具有自我更新、无限增殖能力及致瘤性。大量研究显示,血液系统及实体瘤中均存在CSC。综述了CSC生物学特性的最新研究进展,包括寻找表面标记物、确定CSC微环境、分选与鉴定CSC、探索肿瘤细z胞和CSC之间的转化、研究CSC耐药性和耐药机制。利用肿瘤的这些生物学特性选择性杀伤肿瘤干细胞的靶分子疗法,为克服肿瘤耐药的复发与转移提供新的策略。CSC的研究为人们对肿瘤生物学特性的进一步认识提供了新的思路,并为肿瘤的临床治疗提供了新的希望。

引用

页码：194 / 200

页数：7

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