乳腺癌COX-2、P-gp的表达与新辅助化疗的关系

被引：3

作者：

蔡凤林

周士福

时伟锋

吴玉玉

金琳芳

机构：

[1] 苏州大学附属第四医院

来源：

现代肿瘤医学 | 2008年 / 06期

关键词：

乳腺癌; 新辅助化疗; COX-2; P-gp;

D O I：

暂无

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

摘要：

目的:研究COX-2、P-gp在乳腺癌新辅助化疗前后的表达变化,及其与新辅助化疗疗效的关系。方法:应用免疫组织化学法检测48例乳腺癌新辅助化疗前后标本中COX-2、P-gp的表达。结果:新辅助化疗有效率为70.8%。化疗前后COX-2表达变化显著,由化疗前的62.5%降到化疗后的41.7%,P<0.05;P-gp表达无明显变化。化疗前后COX-2表达与P-gp正相关,P<0.05。新辅助化疗前COX-2、P-gp表达阳性者,化疗效果差,P<0.05。结论:COX-2、P-gp可作为指导乳腺癌化疗并预测化疗敏感性的分子生物学指标。

引用

页码：985 / 988

页数：4

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