肠管平滑肌中Ca2+活化、磷脂依存性蛋白激酶与肌醇磷脂代谢的关系

被引:1
作者
于秉治
肖铮
陈日新
邢伟
机构
[1] 中国医科大学生化教研组
关键词
蛋白激酶; 肌醇磷脂代谢; 丙酮酸激酶; 平滑肌; 磷脂酸丝氨酸; 肠管; Ca; 依存性;
D O I
暂无
中图分类号
学科分类号
摘要
在大白鼠肠管平滑肌中发现了被Ca++所活化、磷脂依存性蛋白激酶(以下简称C-激酶)。此酶存在于细胞的可溶性部分,通常为无活性型,可被Ca++、磷脂和含不饱和脂肪酸的甘油二酯活化。这种活化机制是可逆的。在各种磷脂中磷脂酰丝氨酸最有效。含不饱和脂肪酸的甘油二酯可增加酶的反应速度。C-激酶的活性还可被异博停、地布卡因、丁卡因等能与磷脂结合的药物所抑制。
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页码:657 / 663
页数:7
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