三羟异黄酮对照射小鼠造血系统损伤的防护作用

被引：14

作者：

周永

糜漫天

杨镇洲

机构：

[1] 第三军医大学预防医学院营养卫生学教研室

[2] 大坪医院肿瘤中心

来源：

中华放射医学与防护杂志 | 2005年 / 01期

关键词：

三羟异黄酮; 辐射防护; 造血系统; 骨髓;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

摘要：

目的　探讨三羟异黄酮 (Genistein)对辐射损伤小鼠造血系统的防护作用。方法　 6 0Gyγ射线全身照射BALB c雄性小鼠 ,分 4组 ,照射前 2 4h给予genistein灌胃 ,观察小鼠照射后 30d存活情况及不同时相点有关造血指标的变化 ,同时HE染色观察骨髓病理学改变。结果　Genistein处理组小鼠骨髓照后损伤较R组轻 ,外周血WBC、骨髓有核细胞数和CFU S下降幅度小且恢复较快(P <0 .0 5 ) ,同时genistein能明显延长辐射损伤小鼠的平均存活天数、提高小鼠 30d存活率 (P <0 0 5 ) ,以上结果均与已烯雌酚处理组相似 ,而且genistein对小鼠脾重系数的恢复也有一定的促进作用 (P <0 0 5 )。结论　Genistein能降低辐射对小鼠造血系统的损伤 ,具有一定的辐射保护作用。

引用

页码：25 / 28

页数：4

共 11 条

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