A Model of Focal Cortical Infarctionin Rat:Mini mally Invasive Craniotomy

被引：6

作者：

薛静

高培毅

安沂华

机构：

[1] 首都医科大学附属北京天坛医院神经内科

来源：

中国康复理论与实践 | 2006年 / 01期

关键词：

脑梗死; 动物模型; 大脑中动脉; 大鼠;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞];

学科分类号：

摘要：

目的建立一种稳定的大鼠脑局灶性梗死模型,以用于脑梗死后神经干细胞移植的长期观察。方法37只大鼠随机分为实验组和对照组。微创法经颞骨局部钻孔开颅,采用直接结扎大脑中动脉终段,同时永久结扎同侧颈总动脉、暂时性夹闭对侧颈总动脉的方法制备大鼠脑梗死模型。通过大鼠脑梗死后的神经功能评分、墨汁灌注、TTC染色、MRI成像结果对该模型进行评价。结果大鼠术后状态良好,实验组大鼠观察4周后死亡率低为6 .25 %。大鼠神经功能评分均为1分,墨汁灌注及TTC染色观察梗死范围局限于皮层,4周后MRI成像测量梗死体积稳定,平均为83 .52 mm3。结论该模型对大鼠创伤小,梗死灶的位置和体积恒定,长期存活率高,为脑梗死后神经干细胞移植的研究提供了一种理想的动物模型。

引用

页码：11 / 13+95 +95

页数：4

共 9 条

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