手术治疗2型糖尿病合并肥胖的初步临床经验

被引:6
作者
狄建忠 [1 ]
张弘玮 [1 ]
韩晓东 [1 ]
于浩泳 [2 ]
包玉倩 [2 ]
张频 [1 ]
机构
[1] 上海交通大学附属第六人民医院普外科
[2] 上海交通大学附属第六人民医院内分泌代谢科
关键词
2型糖尿病; 肥胖; 胃旁路术; 疗效; 随访;
D O I
暂无
中图分类号
R656.6 [胃、十二指肠]; R587.1 [糖尿病];
学科分类号
1002 ; 100210 ; 100201 ;
摘要
目的探讨手术治疗肥胖合并2型糖尿病的规范化诊治及疗效。方法收集45例行腹腔镜胃旁路术的糖尿病患者的临床资料,随访并分析其手术前后的一般情况、各项实验室检查指标及并发症情况。结果 45例患者的平均年龄为(44.8±14.2)岁,平均糖尿病病程为(9.5±5.2)年。术后3、6个月患者的体重、腰围、体质指数均较术前显著降低(P值均<0.05)。术后1、3、6个月,患者的空腹血糖、餐后2h血糖、糖化血清白蛋白水平均较术前显著下降(P值均<0.05);糖化血红蛋白水平均较术前有下降趋势,但差异无统计学意义(P值均>0.05)。患者胰岛功能较术前恢复明显。术后3、6个月,患者的三酰甘油水平均较术前显著降低(P值均<0.05),高密度脂蛋白水平均较术前显著升高(P值均<0.05);术后3个月,患者的总胆固醇及低密度脂蛋白水平均较术前显著降低(P值均<0.05)。术后1、3、6个月,患者的维生素B、25羟-维生素D、血钙、血磷水平与术前比较,差异均无统计学意义(P值均>0.05)。术后1例患者因吻合口水肿致吻合口狭窄经保守治疗好转;3例肠梗阻患者,经保守治疗(2例)及行腹腔镜下束带粘连松解术(1例)后缓解。2例患者术后低血糖发作,予调整饮食规律后低血糖发作缓解。结论 2型糖尿病患者行胃旁路术后血糖得到理想控制,规范的治疗流程是手术取得良好疗效的重要保证之一。
引用
收藏
页码:259 / 262
页数:4
相关论文
共 10 条
[1]  
Finding the Optimal Dose of Vitamin D Following Roux-en-Y Gastric Bypass: A Prospective, Randomized Pilot Clinical Trial[J] . Whitney S. Goldner,Julie A. Stoner,Elizabeth Lyden,Jon Thompson,Karen Taylor,Luann Larson,Judi Erickson,Corrigan McBride. &nbspObesity Surgery . 2009 (2)
[2]  
Contribution of adipose tissue to plasma 25-hydroxyvitamin D concentrations during weight loss following gastric bypass surgery. E Lin,D Armstrong-Moore,Z Liang. Obesity (Silver Spring) . 2011
[3]  
Bariatricsurgery versus conventional medical therapy for type 2diabetes. Mingrone G,Panunzi S,De Gaetano A,et al. The New England Journal of Medicine . 2012
[4]  
Bariatric surgery versus intensive medical therapy in obese patients with diabetes. Schauer PR,Kashyap SR,Wolski K, et al. The New England Journal of Medicine . 2012
[5]  
Diabetes in Asia. Ramachandran A,Ma RC,Snehalatha C. The Lancet . 2010
[6]  
Prevalence of diabetes among men and women in China. Yang SH,Dou KF,Song WJ. The New England Journal of Medicine . 2010
[7]  
Relationship of bypassed limb length and remission of type2diabetes mellitus after Roux-en-Y gastric bypass. KAO Y H,LO C H,HUANG C K. Surg Obes Relat Dis . 2012
[8]  
Laparoscopic Roux-en-Y Gastric Bypass for Morbidly Obese Chinese Patients: Learning Curve, Advocacy and Complications[J] . Chih-Kun Huang,Yi-Chia Lee,Chao-Ming Hung,Yaw-Sen Chen,Chi-Ming Tai. &nbspObesity Surgery . 2008 (7)
[9]   中国糖尿病外科治疗专家指导意见(2010) [J].
郑成竹 ;
丁丹 .
中国实用外科杂志, 2011, 31 (01) :54-58
[10]  
Report: Asian Consensus Meeting on Metabolic Surgery. Recommendations for the use of Bariatric and Gastrointestinal Metabolic Surgery for Treatment of Obesity and Type II Diabetes Mellitus in the Asian Population[J] . Muffazal Lakdawala,Aparna Bhasker. &nbspObesity Surgery . 2010 (7)