金葡球菌对亲水或疏水性氟喹诺酮摄入的研究

被引：9

作者：

钟利

冯萍

夏培元

雷秉钧

范昕建

吕晓菊

机构：

[1] 华西医科大学附属第一医院!成都

来源：

中国抗生素杂志 | 2000年 / 01期

关键词：

金葡球菌; 环丙沙星; 托氟沙星; 耐药机制; 荧光测定;

D O I：

10.13461/j.cnki.cja.002703

中图分类号：

R965 [实验药理学];

学科分类号：

摘要：

本实验用荧光测定法研究金葡球菌对环丙沙星、托氟沙星的摄入及能量抑制剂对细菌摄入药物的影响。结果显示:耐药菌对环丙沙星摄入量低于敏感菌,两者对托氟沙星的摄入量没有显著性差异;加入能量抑制剂后,所有细菌对环丙沙星的摄入量均有不同程度增加,除2株敏感菌外,细菌对托氟沙星的摄入没有明显增加。诱导菌对两种药物的摄入量均低于母株:能量抑制剂对细菌摄入环丙沙星、托氟沙星的影响明显不同。表明摄入减少是细菌对两类氟喹诺酮耐药的机制之一,而泵出增加导致的摄入减少仅适合亲水性氟喹诺酮,对疏水性氟喹诺酮目前还难以定论。

引用

页码：58 / 60

页数：3

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