脑卒中后抑郁与脑源性神经营养因子基因Val66Met单核苷酸多态性的相关性研究

被引：4

作者：

卢丽萍

朱英标

成俊英

机构：

[1] 丽水市人民医院神经科

来源：

中国临床神经科学 | 2013年 / 21卷 / 04期

关键词：

脑卒中后抑郁; 脑源性神经营养因子; 基因表达; 单核苷酸;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

目的探讨脑卒中后抑郁(PSD)与脑源性神经营养因子(BDNF)基因Val66Met单核苷酸多态性(SNP)的相互关系。方法选择86例PSD患者为PSD组,68例脑卒中无PSD患者为无PSD组,另选择46名健康者为对照组。3组研究对象年龄及性别基本匹配。采用酶联免疫吸附法检测BDNF浓度和等位基因特异性聚合酶链反应(A-S PCR)技术检测BDNF基因Val66Met位点SNP的分布。结果 PSD组和无PSD组间BDNF表达差异有统计学意义(t=-2.038,P=0.043);两组间基因型频率(χ2=0.340,P=0.844)和等位基因频率(χ2=0.036,P=0.849)差异均无统计学意义。结论 BDNF表达与PSD发生相关,但BDNF基因Val66Met位点SNP与PSD未发现有相关关系。

引用

页码：413 / 417

页数：5

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