脂蛋白相关磷脂酶A2与急性冠状动脉综合征的相关研究

被引：15

作者：

潘晨亮

彭瑜

胡雪婷

江尕学

牟彦红

丁丽琼

张静

张钲

机构：

[1] 兰州大学第一医院心血管内科

来源：

临床心血管病杂志 | 2014年 / 30卷 / 11期

关键词：

脂蛋白相关磷脂酶A2; 急性冠状动脉综合征; 粥样斑块; 冠状动脉病变范围;

D O I：

10.13201/j.issn.1001-1439.2014.11.011

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的:探讨脂蛋白相关磷脂酶A2(lipoprotein associated phospholipase A2,Lp-PLA2)与急性冠状动脉(冠脉)综合征(ACS)的相关性。方法:入选286例因胸痛行冠脉造影患者,其中有165例为ACS(ACS组),73例为稳定型心绞痛(稳定型心绞痛组);48例冠脉造影正常的非冠心病者为对照组,检测各组血浆Lp-PLA2及高敏C反应蛋白(hs-CRP)水平。结果:Lp-PLA2水平在ACS组、稳定型心绞痛组及对照组的水平分别为(115.01±80.74)ng/ml、(90.82±61.58)ng/ml及(82.53±30.89)ng/ml,其中ACS组高于稳定型心绞痛组与对照组(P<0.05)。Hs-CRP水平在ACS组明显高于稳定型心绞痛组及对照组,Lp-PLA2及hs-CRP水平之间无明显相关性。ACS患者血浆Lp-PLA2水平多支冠脉病变组高于单支冠脉病变组(P<0.01),双支冠脉病变组高于单支冠脉病变组(P<0.05)。结论:Lp-PLA2血浆水平可用于间接评估粥样斑块的稳定性及冠脉病变范围。

引用

页码：962 / 965

页数：4

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