局部脑皮层发育不良与癫痫的关系

被引：8

作者：

梁晋川

周晓平

机构：

[1] 第二军医大学长海医院神经外科

来源：

立体定向和功能性神经外科杂志 | 2009年 / 22卷 / 01期

关键词：

局部脑皮层发育不良; NMDAR; GABA能神经元; 癫痫;

D O I：

暂无

中图分类号：

R742.1 [癫痫];

学科分类号：

100204 [神经病学];

摘要：

局部脑皮层发育不良(focal cortical dysplasia,FCD)是皮质发育畸形的一个亚型,其下又有众多分类方法,最常用的是Palmini和Tassi等提出的2种根据组织病理学的分类系统。FCD与胚胎发育早期神经元的增殖、移行、组织等过程密切相关,并且有许多基因和蛋白包括细胞骨架系统相关蛋白、多耐药基因和多耐药蛋白转运体等,均参与了FCD异常细胞的发生,诱发癫痫和导致了癫痫的难治性。目前对FCD引起的药物难治性癫痫无特殊的治疗方法,可以首先尝试使用抗局灶癫痫的药物治疗,其次再考虑行局部病灶的手术切除。根据目前资料,尚不能正确估计两种治疗的预后情况。

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页码：52 / 54

页数：3

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