C反应蛋白基因多态性与缺血性脑卒中的关系

被引：2

作者：

邓可 ^{[1
,2
]}

肖志杰 ^{[3
]}

黎肖弟 ^{[4
]}

机构：

[1] 湖南师范大学附属岳阳医院

[2] 岳阳市二人民医院神经内科

[3] 中南大学湘雅二医院神经内科

[4] 广州广东三九脑科医院

来源：

脑与神经疾病杂志 | 2012年 / 20卷 / 04期

关键词：

超敏C反应蛋白; 基因多态性; 缺血性卒中;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的探讨超敏C反应蛋白(hs-CRP)水平及rs1130864基因多态性与脑梗死(CI)的相关性。方法采用病例对照研究,对105例脑梗死患者和121例健康对照者进行研究。采用免疫透射比浊法测定hs-CRP,用多聚酶链式反应(PCR)和限制性片段长度多态性测定rs1130864基因多态性。患者入院后立即用美国国立卫生院神经功能缺损评分(National Institutes of Health Stroke Scale,NIHSS)对其进行神经功能测评。结果脑梗死组与对照组rs1130864基因型频率分布统计学无显著性差异(P>0.05)。rs1130864与脑梗死病情无关联。脑梗死多因素回归方程的主要危险因素包括高血压史、糖尿病史、吸烟史、HDL-C,hs-CRP水平。结论 rs1130864(1444C>T)基因多态性与脑梗死无关联。

引用

页码：245 / 248

页数：4

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