血清五聚素3浓度在冠状动脉粥样硬化性心脏病中的临床意义

被引:4
作者
赵劲波
雷玉华
向家培
张长江
李元红
机构
[1] 恩施土家族苗族自治州中心医院内科心血管病中心
关键词
冠状动脉疾病; 五聚素3; 临床意义;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
1002 ; 100201 ;
摘要
目的检测冠状动脉粥样硬化性心脏病(冠心病)患者血清五聚素3(pentraxin 3,PTX3)浓度,并探讨其在冠心病的临床意义。方法用酶联免疫吸附试验(ELISA)方法检测150例冠心病患者以及124例健康对照组血清PTX3脂肪因子浓度。结果冠心病组血清中PTX3脂肪因子浓度均明显低于健康对照组,差异有统计学意义[(0.67±0.21)ng/m L vs.(1.41±0.18)ng/m L,P=0.000]。Logistic回归分析表明,PTX3脂肪因子是冠心病的保护因素。血清PTX3诊断冠心病的受试者工作特征曲线(ROC)下面积为0.951(0.921~0.985),最佳截点为465.21 ng/m L(敏感度为72.25%,特异度为89.35%,P=0.021)。结论血清PTX3脂肪因子与临床指标密切相关,它是冠心病保护因素,可用于冠心病诊断。
引用
收藏
页码:735 / 737+748 +748
页数:4
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