血管新生抑制因子在糖尿病微血管并发症中的研究及应用前景

被引：8

作者：

高国全 ^{[1
,2
]}

机构：

[1] 中山大学中山医学院生化教研室

[2] 中山大学中山医学院心血管研究群体

来源：

中山大学学报(医学科学版) | 2017年 / 38卷 / 02期

基金：

高等学校博士学科点专项科研基金; 广东省自然科学基金;

关键词：

血管新生抑制因子; 糖尿病视网膜病变; 糖尿病足; 糖尿病勃起功能障碍; 糖尿病肾病;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

100201 [内科学];

摘要：

糖尿病微血管并发症累及全身各个器官,导致糖尿病患者寿命下降和生活质量降低。血管新生是糖尿病微血管并发症的基本病理特征,而血管新生抑制因子在血管新生平衡调控和糖尿病微血管并发症发生发展中起了重要作用。本文就血管新生抑制因子与糖尿病微血管并发症的研究进展及治疗前景作一综述,包括血管新生抑制因子与糖尿病各种微血管并发症(糖尿病视网膜病变、糖尿病足、糖尿病勃起功能障碍和糖尿病肾病等)等的关系,最后概述了糖尿病微血管并发症的临床治疗现状与内源性新生血管抑制因子在其中的应用前景。

引用

页码：169 / 176

页数：8

共 22 条

[1]

High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells [J].

Che, Di ;

Zhou, Ti ;

Lan, Yuqing ;

Xie, Jinye ;

Gong, Haijun ;

Li, Chaoyang ;

Feng, Juan ;

Hong, Honghai ;

Qi, Weiwei ;

Ma, Caiqi ;

Wu, Qiyuan ;

Yang, Xia ;

Gao, Guoquan .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016, 38 (06) :1815-1822

[2]

Comparison of effects of pioglitazone and glimepiride on plasma soluble RAGE and RAGE expression in peripheral mononuclear cells in type 2 diabetes: Randomized controlled trial (PioRAGE) [J].

Koyama, Hidenori ;

Tanaka, Shinji ;

Monden, Masayo ;

Shoji, Takuhito ;

Morioka, Tomoaki ;

Fukumoto, Shinya ;

Mori, Katsuhito ;

Emoto, Masanori ;

Shoji, Tetsuo ;

Fukui, Mitsuru ;

Fujii, Hisako ;

Nishizawa, Yoshiki ;

Inaba, Masaaki .

ATHEROSCLEROSIS, 2014, 234 (02) :329-334

[3]

Human kallistatin administration reduces organ injury and improves survival in a mouse model of polymicrobial sepsis [J].

Li, Pengfei ;

Bledsoe, Grant ;

Yang, Zhi-Rong ;

Fan, Hongkuan ;

Chao, Lee ;

Chao, Julie .

IMMUNOLOGY, 2014, 142 (02) :216-226

[4]

Elevated Circulation Levels of an Antiangiogenic SERPIN in Patients with Diabetic Microvascular Complications Impair Wound Healing through Suppression of Wnt Signaling [J].

McBride, Jeffrey D. ;

Jenkins, Alicia J. ;

Liu, Xiaochen ;

Zhang, Bin ;

Lee, Kyungwon ;

Berry, William L. ;

Janknecht, Ralf ;

Griffin, Courtney T. ;

Aston, Christopher E. ;

Lyons, Timothy J. ;

Tomasek, James J. ;

Ma, Jian-xing .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2014, 134 (06) :1725-1734

[5]

Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients [J].

Jenkins, Alicia J. ;

Fu, Dongxu ;

Azar, Madona ;

Stoner, Julie A. ;

Kaufman, Derrick G. ;

Zhang, Sarah ;

Klein, Richard L. ;

Lopes-Virella, Maria F. ;

Ma, Jian-xing ;

Lyons, Timothy J. .

JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2014, 28 (03) :353-359

[6]

Acidic/Neutral Amino Acid Residues Substitution in NH2 Terminal of Plasminogen Kringle 5 Exerts Enhanced Effects on Corneal Neovascularization [J].

Li, Cen ;

Li, Lei ;

Cheng, Rui ;

Dai, Zhiyu ;

Li, Chaoyang ;

Yao, Yachao ;

Zhou, Ti ;

Yang, Zhonghan ;

Gao, Guoquan ;

Yang, Xia .

CORNEA, 2013, 32 (05) :680-688

[7]

Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy [J].

Zhou, T. ;

He, X. ;

Cheng, R. ;

Zhang, B. ;

Zhang, R. R. ;

Chen, Y. ;

Takahashi, Y. ;

Murray, A. R. ;

Lee, K. ;

Gao, G. ;

Ma, J-X. .

DIABETOLOGIA, 2012, 55 (01) :255-266

[8]

Overexpression of Pigment Epithelium–Derived Factor Inhibits Retinal Inflammation and Neovascularization.[J].Kyoungmin Park;Ji Jin;Yang Hu;Kevin Zhou;Jian-xing Ma.The American Journal of Pathology.2011, 2

[9]

Repeated intravitreal bevacizumab (Avastin<sup>?</sup>) treatment of persistent new vessels in proliferative diabetic retinopathy after complete panretinal photocoagulation.[J].GeraldSchmidinger;NoemiMaar;MatthiasBolz;ChristophScholda;UrsulaSchmidt‐Erfurth.Acta Ophthalmologica.2011, 1

[10]

Aldo-Keto Reductases in the Eye.[J].Shun Ping Huang;Suryanarayana Palla;Philip Ruzycki;Ross Arjun Varma;Theresa Harter;G. Bhanuprakesh Reddy;J. Mark Petrash;Ram H. Nagaraj.Journal of Ophthalmology.2010,

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