喉癌微血管生成中P53 nm23蛋白和血管内皮生长因子的作用

被引：9

作者：

成伟

李晓明

全成实

郭晓峰

机构：

[1] 长春白求恩医科大学第一临床学院耳鼻咽喉头颈外科,长春白求恩医科大学第一临床学院耳鼻咽喉头颈外科,长春白求恩医科大学第一临床学院耳鼻咽喉头颈外科,长春白求恩医科大学第一临床学院耳鼻咽喉头颈外科

来源：

中华耳鼻咽喉科杂志 | 2000年 / 02期

关键词：

喉肿瘤; 蛋白质P53; 血管生长因子; nm23基因; 微血管密度; 转移;

D O I：

暂无

中图分类号：

R739.65 [喉肿瘤];

学科分类号：

100214 ;

摘要：

目的　探讨P5 3、nm2 3蛋白和血管内皮生长因子 (vascularendothelialgrowthfacor,VEGF)在喉癌微血管生成及转移中的作用。方法　通过免疫组化SP法对 42例喉癌标本中P5 3、nm2 3蛋白、VEGF及微血管密度 (microvesseldensity,MVD)进行了检测。结果　喉癌中P5 3、nm2 3蛋白及VEGF的阳性表达率分别占 47 6 %、5 7 1%和 71 4%。P5 3基因和VEGF呈正相关 (P <0 0 5 ) ,在有淋巴结转移的喉癌标本中P5 3、VEGF阳性表达率及MVD明显高于非转移组 (P <0 0 5 )。而nm2 3基因和VEGF在喉癌标本中无直接相关性 ,在nm2 3蛋白表达阴性和VEGF阳性标本中MVD较高 ,这种现象多见于有淋巴结转移的喉癌中。结论　突变型P5 3基因通过调控VEGF的表达影响肿瘤内MVD ,促使喉癌发生转移 ;而nm2 3基因可能不是通过调控VEGF的表达 ,而是通过其它途径影响喉癌转移。

引用

页码：66 / 68+85

页数：4

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