去骨瓣减压术对大鼠局灶性脑缺血保护作用的有效时间窗

被引：9

作者：

刘正言

周良辅

黄峰平

毛颖

机构：

[1] 复旦大学附属华山医院神经外科!

来源：

中国临床神经科学 | 2001年 / 02期

关键词：

脑缺血; 去骨瓣减压术; 时间窗;

D O I：

暂无

中图分类号：

R651.1 [颅脑];

学科分类号：

1002 ; 100210 ;

摘要：

目的 :探讨去骨瓣减压术对大鼠局灶性脑缺血保护作用的时间窗。方法 :改良Koizumi法制作脑缺血动物模型 ,然后在不同时间点行去骨瓣减压术 ,观察 7d内体重、神经功能和生存率的变化 ,第 7天时取脑行氯化 2 ,3 ,5 三苯基四氮唑 (TTC)染色 ,计算梗死灶面积和体积。结果 :脑缺血后 6、12、2 4h行去骨瓣减压术可显著缩小梗死体积 ,6、12h减压可显著改善神经功能 ,其中以 6h减压的效果最好。结论 :去骨瓣减压术对大鼠局灶性脑缺血具有保护作用 ,其有效时间窗为脑缺血后 2 4h以内

引用

页码：162 / 165

页数：4

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