血管内皮细胞生长因子及有关肢体缺血基因治疗的研究进展

被引：6

作者：

涂兵

金立人

机构：

[1] 华西医科大学附属第一医院普外科!成都

来源：

中国普外基础与临床杂志 | 2000年 / 03期

关键词：

血管内皮细胞生长因子; 肢体缺血; 基因治疗;

D O I：

暂无

中图分类号：

R602 [外科病理学、解剖学];

学科分类号：

1002 ; 100210 ;

摘要：

目的　探讨血管内皮细胞生长因子 (vascularendothelialgrowthfactor ,VEGF)基因治疗严重慢性肢体缺血性疾病的可能性。方法　综述近年来对有关VEGF的分子生物学、VEGF的促血管生成机理及通过基因转移表达VEGF改善缺血肢体血供所进行的研究。结果　临床前的研究显示 ,VEGF能够刺激动物缺血肢体侧支动脉的形成 ,即所谓的“治疗性的血管生成” ;临床结果证实 ,通过基因转移表达的VEGF能够促进新生血管形成 ,使有严重肢体缺血的患者预后明显改善。结论　这项生物技术将为那些药物治疗无效和不适于外科血管重建或置换术的严重肢体缺血性疾病患者提供一种新的治疗方法。

引用

页码：202 / 204

页数：3

共 16 条

[1]

Molecular and biological properties of the vascular endothelial growth factor family proteins〔J〕. Ferrara N,Houck K,Jakeman L,et al. Endocrine Reviews . 1992

[2]

Vascular endothelial growth factor in ocular fluids of patients with diabetic retinopathy and other retinal disorder〔J〕. Aiello LP,Avery AL,Arrigg PG,et al. The New England Journal of Medicine . 1994

[3]

Therapeutic angiogenesis: a single intra-arterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model〔J〕. Takeshita S,Zheng LP,Borgi E,et al. The Journal of Clinical Investigation . 1994

[4]

Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia 〔J〕. Takeshita S,Pu LQ,Stein LA,et al. Circulation . 1994

[5]

Arterial gene therapy for theraputic angiogenesis in patients with peripheral artery disease〔J〕. Isner JM,Walsh K,Symes J,et al. Circulation . 1995

[6]

Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo 〔J〕. Takeshita S,Tsurumi Y,Couffinhal T,et al. Laboratory Investigation . 1996

[7]

Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia 〔J〕. Baumgartner I,Pieczek A,Manor O,et al. Circulation . 1998

[8]

Fate of the patient with chronic leg ischemia〔J〕. Dormancly J,Mahir M,Ascady G,et al. Journal of Thoracic and Cardiovascular Surgery . 1989

[9]

Pituitary follicular cells secrete a novel heparinbinding growth factor specific for vascular endothelial cells 〔J〕. Ferrara N,Henzel WJ. Biochemical and Biophysical Research Communications . 1989

[10]

Direct gene transfer into mouse muscle in vivo〔J〕. Wolff JA,Malone RW,Williams P,et al. Science . 1990

← 1 2 →