嘌呤类似物治疗炎症性肠病的药理作用和临床应用

被引：7

作者：

郑家驹

机构：

[1] 苏州市消化系疾病与营养研究中心苏州市第三人民医院消化内科

来源：

胃肠病学 | 2003年 / 04期

关键词：

炎症性肠病; TPMT; 药理作用; 类似物; 同型物; 免疫调节剂; 剂量依赖性; IBD; 维持缓解; 安慰剂; 空白剂; 临床应用;

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

1002 ; 100201 ;

摘要：

<正> 1990年以前,仅有少数医疗中心将免疫调节剂用于炎症性肠病(IBD)患者,其适应证和疗效也颇具争议性,近10年来则积累了很多临床经验。目前已有硫唑嘌呤(AZA)、6-巯基嘌呤(6-MP)、甲氨蝶呤(MTX)、霉酚酸酯(商品名:骁悉)、他克莫司(商品名:普乐可复)和环孢素A等几大类化学性免疫抑制剂以及生物制剂(抗肿瘤坏死因子单克隆抗体等)应用于临床,其中尤以AZA和6-MP应用得较早、较广。本文就此两种药物治疗克罗恩病(CD)和溃疡性结肠炎(UC)的药理作用以及临床应用现状和进展作一综述。

引用

页码：253 / 255

页数：3

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