蛋白激酶C和IkΒNFkΒ在免疫调节中的作用

被引:11
作者
谭余庆
张永祥
机构
[1] 军事医学科学院毒物药物研究所!北京
关键词
蛋白激酶C; NF-κΒ; ΙκΒ; 淋巴细胞;
D O I
10.13431/j.cnki.immunol.j.20000149
中图分类号
R346 [];
学科分类号
摘要
蛋白激酶C是一组重要的细胞内信号转导物质, 它磷酸化下游 元件IκB,使其活化并分解小分子蛋白NF-κB,该小分子蛋白对淋巴细胞的活化、淋巴细胞的凋亡以及淋巴细胞介导的细胞毒作用有着重要的调控作用。NF-κB与IκB-α是一组相互调节的系统,其中一个成分调节水平的改变可影响另一个成分的活性;这些成分活性的改变又可反馈性调节PKC的活性。
引用
收藏
页码:464 / 467
页数:4
相关论文
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