微量热法研究药物对肿瘤细胞的诱导分化作用

被引：6

作者：

谭安民

徐波

屈松生

机构：

[1] 武汉大学化学系!武汉

[2] 天然药物及仿生药物国家重点实验室!北京

来源：

物理化学学报 | 1996年 / 09期

关键词：

微量热法; HL－60细胞; 诱导分化;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

摘要：

Sp-Octyl-(8-Chloroadenosine)-3',5'-Cyclophosphate (OCC), a newlysynthesized cAMP analog, strongly induces growth inhibition and differentiation in human promyelocytic leukemia HL-60 cells. The effect of OCC is dose-time dependent. By using the LKB2277 Bioactivity Monitor,we determined the heat production rate of HL-60 cells treated by OCC at different concentrations. It was found that the heat production rate of HL-60 cell treated by OCC gradually decreased to that of normal human neutrophiles.

引用

页码：849 / 851

页数：3