川芎嗪对人类血小板的药理作用

被引：54

作者：

周序斌

L.Salganicoff

R.Sevy

机构：

[1] 山东医学院药理学教研室

[2] Temple University School of Medicine

[3] Philadelphia

[4] Pa USA

[5] Pa

来源：

药学学报 | 1985年 / 05期

关键词：

川芎嗪; 血小板; 环磷酸腺苷; Ca2+;

D O I：

10.16438/j.0513-4870.1985.05.004

中图分类号：

学科分类号：

摘要：

川芎嗪对收缩状态的Salganicoff′s人血小板条有松弛作用,ID80约160μg/ml。明显抑制ADP、花生四烯酸和TXA2同类物SQ26655所引起的收缩效应。能使血小板cAMP含量升高近1倍,随给药剂量增加,张力继续降低,但cAMP含量并不继续增加。用腺苷环化酶抑制剂SQ 22536后,川芎嗪对钙离子载体（calcium ionophore）A 23187所引起的血小板条收缩效应呈抑制作用,提示川芎嗪松弛血小板条的作用可能与抑制Ca2+作用有关。

引用

页码：334 / 339

页数：6

共 7 条

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