顺铂抗癌作用及其对肾功能的影响

被引：5

作者：

秋肖凡

李自新

机构：

[1] 北京医科大学人民医院妇产科

来源：

国外医学妇产科学分册. | 1990年 / 01期

关键词：

顺铂; 肾毒性; 抗癌作用; 高张盐水; 肾功能;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

顺铂是一种细胞毒性抗癌药,具有广谱性,抗癌作用明显,尤其对卵巢、睾丸、膀胱癌及头颈部肿瘤有效。主要副作用为肾毒性、耳毒性及胃肠反应。本文综述顺铂的作用机理及其对肾功能影响,并概述几种减轻肾功能损伤的防护措施,主要为:1.延长给药时间;2.使用利尿剂,甘露醇;3.大剂量水化;4.使用高张盐水;5.使用硫代硫酸钠。

引用

页码：7 / 10

页数：4

共 5 条

[1] EVALUATION OF THE EFFECT OF FUROSEMIDE ON ULTRAFILTERABLE PLATINUM KINETICS IN PATIENTS TREATED WITH CIS-DIAMMINEDICHLOROPLATINUM
DUMAS, M
DEGISLAIN, C
DATHIS, P
CHADOINTNOUDEAU, V
ESCOUSSE, A
GUERRIN, J
AUTISSIER, N
[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1989, 23 (01) : 37 - 40
[2] SODIUM THIOSULFATE FAILS TO INCREASE THE THERAPEUTIC INDEX OF INTRAVENOUSLY ADMINISTERED CIS-DIAMMINEDICHLOROPLATINUM(II) IN MICE BEARING MURINE AND HUMAN-TUMORS
AAMDAL, S
FODSTAD, O
PIHL, A
[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1988, 21 (02) : 129 - 133
[3] DNA cross-linking following exposure to cis -platinum in primary and serially passaged cultured cells derived from two murine fibrosarcomas[J] . David Murray,Ivan Basic,Luka Milas,Raymond E. Meyn.Cancer Chemotherapy and Pharmacology . 1987 (2)
[4] A MODEL FOR ULTRAFILTERABLE PLASMA PLATINUM DISPOSITION IN PATIENTS TREATED WITH CISPLATIN
REECE, PA
STAFFORD, I
RUSSELL, J
KHAN, M
GILL, PG
[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1987, 20 (01) : 26 - 32
[5] PROTECTION OF ANTIPROLIFERATIVE EFFECT OF CIS-DIAMMINEDICHLOROPLATINUM(II) BY SODIUM THIOSULFATE
ABE, R
AKIYOSHI, T
TSUJI, H
BABA, T
[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1986, 18 (02) : 98 - 100

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