类风湿关节炎血清和滑液Th1/Th2细胞因子的水平及意义

被引：5

作者：

冷建杭

蒋群芳

姜晓虹

卓广超

王克义

汪子伟

机构：

[1] 杭州市第一人民医院中心实验室,杭州市第一人民医院中心实验室,杭州师范学院医学院药理教研组,杭州市第一人民医院中心实验室,杭州市第一人民医院中心实验室,杭州市第一人民医院中心实验室,,,,,

来源：

浙江临床医学 | 2004年 / 06期

关键词：

类风湿关节炎; Th1/Th2细胞; 细胞因子;

D O I：

暂无

中图分类号：

R593.22 [类风湿性关节炎];

学科分类号：

1002 ; 100201 ;

摘要：

目的初步探讨类风湿关节炎患者免疫功能紊乱的机制。方法采用酶联免疫吸附法 (ELISA)检测类风湿关节炎患者血清和关节滑膜液中Th1细胞分泌的细胞因子IL -2、IFN -γ和Th2细胞分泌的细胞因子IL-6、IL -10的水平。结果类风湿关节炎患者血清及滑膜液中IL-2、IFN -γ的水平与正常对照组相比明显升高 ,差异具有显著性 ( p<0.01或 p<0.05) ,而IL -6、IL -10的水平降低 ,差异具有显著性 ( p<0.01或p<0.05)。结论在类风湿关节炎患者血清及滑膜液中Th1/Th2细胞分泌的细胞因子水平存在着明显失衡 ,两者以Th1细胞分泌细胞因子占优势 ,这可能与其发病机制密切相关。

引用

页码：457 / 458

页数：2

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