CD40/CD40L系统与动脉粥样硬化

被引：3

作者：

王毓婧

刘亚民

机构：

[1] 西安交通大学第一附属医院脑血管病科

来源：

国际脑血管病杂志 | 2013年 / 21卷 / 12期

关键词：

抗原,CD40; CD40配体; 动脉粥样硬化; 炎症;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

动脉粥样硬化是一种慢性炎症性疾病。动脉粥样硬化斑块破裂和血栓形成可导致急性心脑血管事件。炎性介质CD40/CD40L广泛存在于与动脉粥样硬化相关的细胞,参与斑块内炎症反应,释放促炎细胞因子,降解细胞外基质,提高促凝活性,促进动脉粥样硬化的进展和斑块易损性。干预CD40/CD40L信号系统可能成为减缓动脉粥样硬化进展和稳定动脉粥样硬化斑块的一种有效治疗策略。

引用

共 32 条

[1]

CD40 Ligand: A neo-inflammatory molecule in vascular diseases.[J].Ghada S. Hassan;Yahye Merhi;Walid Mourad.Immunobiology.2011, 5

[2]

Binding of CD40L to Mac-1's I-Domain Involves the EQLKKSKTL Motif and Mediates Leukocyte Recruitment and Atherosclerosis-But Does Not Affect Immunity and Thrombosis in Mice [J].

Wolf, Dennis ;

Hohmann, Jan-David ;

Wiedemann, Ansgar ;

Bledzka, Kamila ;

Blankenbach, Hermann ;

Marchini, Timoteo ;

Gutte, Katharina ;

Zeschky, Katharina ;

Bassler, Nicole ;

Hoppe, Natalie ;

Rodriguez, Alexandra Ortiz ;

Herr, Nadine ;

Hilgendorf, Ingo ;

Stachon, Peter ;

Willecke, Florian ;

Duerschmied, Daniel ;

von zur Muhlen, Constantin ;

Soloviev, Dmitry A. ;

Zhang, Li ;

Bode, Christoph ;

Plow, Edward F. ;

Libby, Peter ;

Peter, Karlheinz ;

Zirlik, Andreas .

CIRCULATION RESEARCH, 2011, 109 (11) :1269-U202

[3]

The CD40-CD40L system in cardiovascular disease [J].

Pamukcu, Burak ;

Lip, Gregory Y. H. ;

Snezhitskiy, Viktor ;

Shantsila, Eduard .

ANNALS OF MEDICINE, 2011, 43 (05) :331-340

[4]

The immunobiology of CD154–CD40–TRAF interactions in atherosclerosis.[J].David Engel;Tom Seijkens;Marjorie Poggi;Maryam Sanati;Larissa Thevissen;Linda Beckers;Erwin Wijnands;Dirk Lievens;Esther Lutgens.Seminars in Immunology.2009, 5

[5]

Thromboxane A 2 promotes soluble CD40 ligand release from human platelets.[J].Yukiko Enomoto;Seiji Adachi;Rie Matsushima-Nishiwaki;Tomoaki Doi;Masayuki Niwa;Shigeru Akamatsu;Haruhiko Tokuda;Shinji Ogura;Shinichi Yoshimura;Toru Iwama;Osamu Kozawa.Atherosclerosis.2009, 2

[6]

Intracoronary versus intravenous abciximab administration in patients with ST-elevation myocardial infarction undergoing thrombus aspiration during primary percutaneous coronary intervention-Effects on soluble CD40 ligand concentrations [J].

Dominguez-Rodriguez, Alberto ;

Abreu-Gonzalez, Pedro ;

Avanzas, Pablo ;

Bosa-Ojeda, Francisco ;

Samimi-Fard, Sima ;

Marrero-Rodriguez, Francisco ;

Kaski, Juan Carlos .

ATHEROSCLEROSIS, 2009, 206 (02) :523-527

[7]

Innate and adaptive immunity in atherosclerosis [J].

Packard, Rene R. S. ;

Lichtman, Andrew H. ;

Libby, Peter .

SEMINARS IN IMMUNOPATHOLOGY, 2009, 31 (01) :5-22

[8]

Different behaviour of soluble CD40L concentrations can be reflected by variations of preanalytical conditions.[J].F. Jung;S. Forconi;N. Antonova;F. Wenzel;A. Baertl;N. Zimmermann;Th. Hohlfeld;G. Giers;J. Oldenburg;R. Assert.Clinical Hemorheology and Microcirculation.2008, 1–4

[9]

The ELAPSE (Evaluation of Long-Term Clopidogrel Antiplatelet and Systemic Anti-Inflammatory Effects) Study [J].

Saw, Jacqueline ;

Madsen, Esben Hjorth ;

Chan, Sammy ;

Maurer-Spurej, Elisabeth .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (23) :1826-1833

[10]

CD40-induced countercurrent conduits for tumor escape or elimination? [J].

Murugaiyan, Gopal ;

Martin, Sunil ;

Saha, Bhaskar .

TRENDS IN IMMUNOLOGY, 2007, 28 (11) :467-473

← 1 2 3 4 →