他汀治疗对心力衰竭的影响

被引:18
作者
潘国忠 [1 ]
胡大一 [2 ]
机构
[1] 北京煤炭总医院心内科
[2] 北京大学人民医院心内科
关键词
他汀; 心力衰竭; 预后;
D O I
暂无
中图分类号
R541.6 [血液循环衰竭];
学科分类号
1002 ; 100201 ;
摘要
大量基础研究和临床试验显示,他汀类治疗可以使心力衰竭的患者获益,其可能的保护机制是多方面的,包括抗炎、改善血管内皮功能、抑制神经激素活性以及改善心肌重塑等等,而且这些保护机制与血脂的降低无关。
引用
收藏
页码:744 / 748
页数:5
相关论文
共 13 条
[1]  
Class effects of statins in elderly patients with congestive heart failure: A population-based analysis[J] . Stéphane Rinfret,Hassan Behlouli,Mark J. Eisenberg,Karin Humphries,Jack V. Tu,Louise Pilote.American Heart Journal . 2008 (2)
[2]  
Double-Blind, Randomized, Placebo-Controlled Study of High-Dose HMG CoA Reductase Inhibitor Therapy on Ventricular Remodeling, Pro-Inflammatory Cytokines and Neurohormonal Parameters in Patients With Chronic Systolic Heart Failure[J] . Henry Krum,Emma Ashton,Christopher Reid,Victor Kalff,Jim Rogers,John Amarena,Bhuwan Singh,Andrew Tonkin.Journal of Cardiac Failure . 2007 (1)
[3]   Comparison of frequency of new-onset atrial fibrillation or flutter in patients on statins versus not on statins presenting with suspected acute coronary syndrome [J].
Ramani, Gautam ;
Zahid, Maliha ;
Good, Chester B. ;
Macioce, Alanna ;
Sonel, Ali F. .
AMERICAN JOURNAL OF CARDIOLOGY, 2007, 100 (03) :404-405
[4]  
Effect of High-Dose Atorvastatin on Hospitalizations for Heart Failure: Subgroup Analysis of the Treating to New Targets (TNT) Study[J] . Kiran K. Khush,David D. Waters,Vera Bittner,Prakash C. Deedwania,John J.P. Kastelein,Sandra J. Lewis,Nanette K. Wenger.Circulation . 2007 (5)
[5]  
Intensive Statin Therapy and the Risk of Hospitalization for Heart Failure After an Acute Coronary Syndrome in the PROVE IT–TIMI 22 Study[J] . Benjamin M. Scirica,David A. Morrow,Christopher P. Cannon,Kausik K. Ray,Marc S. Sabatine,Petr Jarolim,Amy Shui,Carolyn H. McCabe,Eugene Braunwald.Journal of the American College of Cardiology . 2006 (11)
[6]   Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure [J].
Sola, S ;
Mir, MQS ;
Lerakis, S ;
Tandon, N ;
Khan, BV .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (02) :332-337
[7]   Statins and mortality among elderly patients hospitalized with heart failure [J].
Foody, JM ;
Shah, R ;
Galusha, D ;
Masoudi, FA ;
Havranek, EP ;
Krumholz, HM .
CIRCULATION, 2006, 113 (08) :1086-1092
[8]   Pravastatin suppresses the increase in matrix metalloproteinase-2 levels after acute myocardial infarction [J].
Nakaya, R ;
Uzui, H ;
Shimizu, H ;
Nakano, A ;
Mitsuke, Y ;
Yamazaki, T ;
Ueda, T ;
Lee, JD .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2005, 105 (01) :67-73
[9]   Statin therapy is associated with lower mortality among patients with severe heart failure [J].
Mozaffarian, D ;
Nye, R ;
Levy, WC .
AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (09) :1124-1129
[10]   Statins and the role of nitric oxide in chronic heart failure [J].
von Haehling, S ;
Anker, SD ;
Bassenge, E .
HEART FAILURE REVIEWS, 2003, 8 (01) :99-106